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Win32/Stuxnet is almost certainly the most sophisticated virus yet developed for targeted attacks.  Stuxnet is parasite code that focuses on subverting SCADA systems, the automated monitoring and control systems of many modern manufacturing, production, power generation, transmission and distribution, fabrication, water treatment and distribution, wastewater collection and treatment, oil and gas refining and transmission, and communication systems.  Many SCADA software vulnerabilities can potentially be exploited by Stuxnet.  All current and future efforts to secure infrastructure must now adapt to and address this potential new mode of attack on our infrastructure.